Oxbryta is a medication used to treat sickle cell disease (SCD). However, alarming reports have recently linked Oxbryta to serious — and potentially deadly — health problems, including stroke, organ failure, blood clots, and even death. Our firm is actively investigating these claims — if you’ve been diagnosed with a qualifying health problem after taking Oxbryta for SCD, you may be entitled to compensation.
Please call 1-800-525-7111 and let us review your case for free. At Riddle & Riddle Injury Lawyers, we’re there for you When Justice Counts™ — and we’re ready to help however we can.
In this blog post, we’ll summarize recent developments in Oxbryta lawsuits as of early summer 2025, and share what you need to know to protect your legal rights.
2025 Developments in the Oxbryta Lawsuit
As of June 2025, Oxbryta (voxelotor) lawsuits are in the early stages of litigation. While no verdicts or settlements have been made public yet, multiple Oxbryta lawsuits have been filed, and trial dates are being scheduled.
One major development is a federal case in California, which is currently set to go to trial in June 2027. Additional cases have been filed in other states, including Illinois, as more patients step forward with claims against Pfizer.
IMPORTANT: Pfizer and other defendants in these lawsuits strongly deny any liability and/or wrongdoing.
Why These Lawsuits Matter to Consumers
Alleged Harms Linked to Oxbryta
Patients taking Oxbryta have reported serious health complications, including:
- Strokes
- Organ failure
- Blood clots and cardiovascular issues
- Increased vaso-occlusive crises (painful sickle cell episodes)
- Death
These lawsuits allege that manufacturers failed to properly worn both patients and physicians about these risks.
Safety Announcements and Withdrawal
In September 2024, Pfizer voluntarily withdrew Oxbryta from the global market. The decision followed updated trial and registry data showing an increased risk of adverse outcomes, including fatal events and worsening of sickle cell disease symptoms.
The FDA also issued a safety alert advising patients and providers to discontinue use of the drug. Prior to this, in August 2023, label updates were made, but they did not include warnings about the most severe risks now being litigated.
Timeline of Key Events
- November 2019: Oxbryta receives FDA approval for patients aged 12 and older
- December 2021: FDA expands approval to children aged 4–11
- August 2023: Label updated, but still lacking critical safety warnings
- September 2024: Pfizer voluntarily withdraws the drug
- November 2024 – Present: Lawsuits begin filing, including cases alleging stroke and death
- June 2027: First federal trial scheduled in California
What It Means for Patients and Families
No Verdicts Yet — But a Clear Signal
While no judgments have been handed down yet, the scheduling of trials is a strong indicator that the courts are taking these allegations seriously. The upcoming 2027 trial will be the first major test of claims against the drugmakers.
Who May Be Eligible to File an Oxbryta Lawsuit
You may be able to file a claim or lawsuit if you meet the following criteria:
- The person took Oxbryta after November 25, 2019 (if they were 12 or older at first use)
- OR the person took Oxbryta after December 17, 2021 (if they were 4 or older at first use)
- They must have been diagnosed with a variant of sickle cell disease
- They must have taken Oxbryta at least once daily
- There must be medical documentation showing the development or worsening of one or more of the following conditions after starting Oxbryta:
- Vaso-occlusive crises
- Acute chest syndrome
- Hepatic or kidney failure
- Stroke or blood clots
- Serious infections such as pneumonia
- Bone necrosis, arthritis, or leg ulcers
- Pulmonary hypertension or vision loss
- Priapism or splenic sequestration
- Sleep apnea or other sleep-disordered breathing
- Death following consistent use
Time is of the essence, and your claim may be subject to the statute of limitations. Call 1-800-525-7111 today to speak with an experienced Oxbryta lawsuit attorney who can advise you on your legal rights and recommend your best available options.
What to Expect from the First Trial in 2027
The upcoming California trial will examine whether Pfizer and GBT failed to inform patients and healthcare providers about the dangers of Oxbryta. Internal documents and clinical trial data will likely be central to the case.
A ruling in favor of the plaintiff could set the tone for future settlements and increase awareness of post-approval drug monitoring and patient safety.
Key Takeaways
- Lawsuits are still in the early stages, but the first trial is set for 2027
- Oxbryta was withdrawn from the market due to severe risks
- Patients may be eligible for compensation if they were harmed after taking the drug
- Time is limited to file a claim, so acting early is important
What Should You Do If You Were Affected?
Speak with your doctor about any symptoms or complications you’ve experienced since taking Oxbryta. Request your medical records and document any hospital visits or diagnoses related to stroke, organ damage, or pain crises.
Next, reach out to Riddle & Riddle Injury Lawyers to speak with an attorney with experience in pharmaceutical injury cases. These cases can be complex, and having the right legal team makes all the difference.
Riddle & Riddle Is Here to Help
At Riddle & Riddle Injury Lawyers, we’ve handled numerous dangerous drug lawsuits and have the resources to thoroughly investigate your claim. Our team is currently accepting Oxbryta cases and is committed to helping patients and their families get the justice they deserve.
We offer free case reviews, and you won’t pay anything unless we win.
Call 1-800-525-7111 today for your free consultation. If Oxbryta has harmed you or someone you love, don’t wait. Let us fight for the justice you deserve.
Justice Counts — and so do you.
For more information, please contact Riddle & Riddle Injury Lawyers to schedule a free consultation with a personal injury lawyer in North Carolina today. We have five convenient locations in North Carolina, including Greenville, Raleigh, Goldsboro, Jacksonville, Kinston, Charlotte, Greensboro, Durham, Fayetteville, Wilmington, Winston-Salem & Garner.
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